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Isotane nz, a diazepine, has been used since the sixties to treat seizures. Today, diazepam is also isotane 20 used to treat anxiety, depression, and chronic pain. Unlike phenytoin, however, benzodiazepines have the opposite potential of phenytoin--they increase the sensitivity central nervous system to seizures. The current study, by a research team headed Dr. James F. Klimaszewicz of the Sackler School Medicine at Tel Aviv University, evaluated the safety and pharmacology of a ketamine-based drug for the treatment of epilepsy in children and adolescents. The drug, called N-acetylcysteine, is an amino acid that can be dissolved in water. N-acetylcysteine is also a potential candidate for treatment of bipolar disorder. Unlike ketamine and phenytoin, a common antiserum used to reduce seizure frequency, N-acetylcysteine does not depress the central nervous system. It also doesn't cause hallucinations. In a study on mice, the researchers administered N-acetylcysteine for ten minutes or longer every other day between 6-12 months old. The next year, they measured animals' seizure thresholds using a simple visual reaction time test. They found that the animals given drug had lower seizure thresholds, were less active during seizures, and they didn't experience any hallucinations. In fact, the animals that received 10 mg/kg (20 mg/lb) or higher doses of the drug were about as responsive to the animal test as animals that were receiving a daily dose of phenytoin. "We believe that by reducing the seizure threshold to near normal levels, N-acetylcysteine may increase overall seizure prevention and reduce the chance that isotane 20mg a seizure will lead to irreversible brain damage," said Dr. Klimaszewicz. The researchers further found that N-acetylcysteine did not cause the loss of memory or attention that can sometimes occur with phenytoin. Instead, N-acetylcysteine protected against learning and memory deficits that were accompanied by abnormal behaviors in the animals. This was observed in both male and female mice. "Since N-acetylcysteine doesn't depress the central nervous system, it will not aggravate or worsen side effects of phenytoin and diazepam," said Dr. Klimaszewicz. The authors note that study provides one more potential avenue for the rapid development of new treatment options for seizures in children and adolescents. The researchers hope that drug will be available in the first half of next year by which time they aim to take about 250 young animals out of the study for evaluation and control experiments. This would be a "proof of concept" study, said Dr. Klimaszewicz. "We would like to move a larger test population of at least 1000, in order to more precisely measure the drug's effects in human epilepsy patients." The study coauthors are: Dr. Avi Karp, Prof. Yaacov Neria, Ofer Levy, and Dr. Amit Steinberg from the Sackler School of Medicine, Dr. Ronit Eren, Tel Aviv University's Department of Clinical and Translational Neurosciences, Prof. Yitzchak Eren of the Sackler School Medicine. The research was funded by National Science Foundation, the Ramot Group, National Institutes of Health, the American Epilepsy Society, and Israeli Ministry of Health. About the Sackler School of Medicine at Tel Aviv University The Sackler School of Medicine at Tel Aviv University is one of the world's leading interdisciplinary centers for neuroscience training and research. The School brings together more than 100 academic departments and more than 1,400 researchers through programs of study in neuroscience, and other disciplines. The School offers programs that cover advanced Where to buy viagra in melbourne australia research skills, clinical care, and education that benefit the entire Israeli community. Currently, School is studying the effects of early childhood developmental deprivation on neurodevelopment and the brain at cellular level. The Sackler School of Medicine was established in 1962 to ensure that Israel had a world-class biomedical school to serve the medical needs of nation. In recent years, the School has developed strong ties with the world's leading academic medical centers including Harvard, Stanford, Yale, the University of Wisconsin-Madison, Mayo Clinic in Rochester, New York, the Mayo Foundation for Medical Education in Rochester, Minnesota, and Tel Aviv isotane new zealand University. The School works closely with leading educational institutions including the College of Medicine, Hebrew University Jerusalem, Tel Aviv University, Arava Medical Center, Hebrew University of Jerusalem, Isotane 10mg $183.2 - $0.68 Per pill Ben-Gurion the Negev, and Heidelberg University. For more information, please visit www.sackler.ac.il About the American Epilepsy Society

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